From the labs of Prof. Robert Langer and Prof. Klavs Jensen of Massachusetts
Institute of Technology the long existing
incapability of old technologies for Intracellular delivery of
macromolecules is now overcome with the development of new
advanced microfluidic methods for
intracellular delivery, The concept of
cell squeezing states that a rapid disruption of the cell membrane is induced
due to squeezing which is transient in nature and thus allows
intracellular delivery of macromolecules without bringing in use of any toxic external factor. This research and
development eventually led to Cell Squeezing platform.
Microfluidic delivery platform is a device, is made up of channels carved into a silicon microchip through which cells at first can stream freely. Nonetheless, as the cells travel through the device like an inward tube along a water slide—the channel width limits until a cell ends up in a tight spot—compelled to fit through a space that is narrower than the cell. The supple cell film permits the cell to press through the constriction. Nonetheless, the constrained, quick change fit as a fiddle makes brief gaps in the cell film, without forever harming or executing the cell.
Microfluidic delivery platform is a device, is made up of channels carved into a silicon microchip through which cells at first can stream freely. Nonetheless, as the cells travel through the device like an inward tube along a water slide—the channel width limits until a cell ends up in a tight spot—compelled to fit through a space that is narrower than the cell. The supple cell film permits the cell to press through the constriction. Nonetheless, the constrained, quick change fit as a fiddle makes brief gaps in the cell film, without forever harming or executing the cell.
The application of Cell squeezing are highly impacting some examples are training the immune system to fight the
Cancer, regenerating damaged tissue understanding sickness mechanisms and authenticating
drug candidates for clinical trials.
